Chiara Anselmi
Postdoctoral Scholar, Stem Cell Biology and Regenerative Medicine
Faculty Lab:
My expertise is in the areas of regeneration, evolution, the nervous system and cell biology. I use a marine colonial tunicate, Botryllus schlosseri, characterized by having robust regenerative capabilities and an assayable and frequent (weekly) CNS (Central nervous system) tissue regeneration and loss throughout adult life. I believe that comparative studies on a simple chordate can help us elucidate the principal mechanisms that are the foundation of regeneration and aging.
I use a multidisciplinary methodology that integrates advanced single cell RNAseq, imaging, multi-parameter flow cytometric isolation of cellular populations and transplantation assays to elucidate the cellular and genetic changes associated with neuronal degeneration process in young and old colonies.
I use a multidisciplinary methodology that integrates advanced single cell RNAseq, imaging, multi-parameter flow cytometric isolation of cellular populations and transplantation assays to elucidate the cellular and genetic changes associated with neuronal degeneration process in young and old colonies.
Publications
Anselmi, C., Kowarsky, M., Gasparini, F., Caicci, F., Ishizuka, K. J., Palmeri, K. J., … Manni, L. (2022). Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate. Proceedings of the National Academy of Sciences of the United States of America, 119(29), e2203032119.
2022
Vanni, V., Salonna, M., Gasparini, F., Martini, M., Anselmi, C., Gissi, C., & Manni, L. (2022). Yamanaka Factors in the Budding Tunicate Botryllus schlosseri Show a Shared Spatio-Temporal Expression Pattern in Chordates. Frontiers in Cell and Developmental Biology, 10, 782722.
2022
Manni, L., Caicci, F., Anselmi, C., Vanni, V., Mercurio, S., & Pennati, R. (2022). Morphological Study and 3D Reconstruction of the Larva of the Ascidian Halocynthia roretzi. JOURNAL OF MARINE SCIENCE AND ENGINEERING, 10(1).
2022
Ballarin, L., Karahan, A., Salvetti, A., Rossi, L., Manni, L., Rinkevich, B., … Drobne, D. (2021). Stem Cells and Innate Immunity in Aquatic Invertebrates: Bridging Two Seemingly Disparate Disciplines for New Discoveries in Biology. Frontiers in Immunology, 12, 688106.
2021
Kowarsky, M., Anselmi, C., Hotta, K., Burighel, P., Zaniolo, G., Caicci, F., … Voskoboynik, A. (2021). Sexual and asexual development: two distinct programs producing the same tunicate. Cell Reports, 34(4), 108681.
2021
Lara-Ramirez, R., Perez-Gonzalez, C., Anselmi, C., Patthey, C., & Shimeld, S. M. (2019). A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait. DEVELOPMENT, 146(1).
2019
Manni, L., Anselmi, C., Cima, F., Gasparini, F., Voskoboynik, A., Martini, M., … Ballarin, L. (2019). Sixty years of experimental studies on the blastogenesis of the colonial tunicate Botryllus schlosseri. DEVELOPMENTAL BIOLOGY, 448(2), 293–308.
2019
Manni, L., Anselmi, C., Burighel, P., Martini, M., & Gasparini, F. (2018). Differentiation and Induced Sensorial Alteration of the Coronal Organ in the Asexual Life of a Tunicate. INTEGRATIVE AND COMPARATIVE BIOLOGY, 58(2), 317–28.
2018
Stach, T., & Anselmi, C. (2015). High-precision morphology: bifocal 4D-microscopy enables the comparison of detailed cell lineages of two chordate species separated for more than 525 million years. BMC BIOLOGY, 13, 113.
2015
